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Selected publications

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M Nasralla, H Laurent, O. Alderman, TF Headen, L Dougan Trimethylamine-N-oxide depletes urea in a peptide solvation shell, PNAS, 121(14) e2317825121(2024)

H Laurent, MDH Hughes, M Walko, DJ Brockwell, N Mahmoudi, TGA Youngs, TF Headen, L Dougan Visualisation of self-assembly and hydration of a beta-hairpin through integrated small and wide-angle neutron scattering, Biomacromolecules, 24(11), 4869 (2023)

MDH Hughes, SE Cussons, BS Hanson, KR Cook, T Feller, N Mahmoudi, DL Baker, R Ariens, DA Head, DJ Brockwell, L Dougan Building block aspect ratio controls assembly, architecture and mechanics of synthetic and natural protein networks, Nature Communications, 14(1), 5593 (2023)

A Aufderhorst-Roberts, S Cussons, DJ Brockwell L Dougan, Diversity of viscoelastic properties of an engineered muscle-inspired protein hydrogel, Soft Matter, 2023, 19, 3167
DOI: 10.1039/D2SM01225A

K Cool, D Head, L Dougan, Modelling network formation by cluster aggregation kinetics, Soft Matter, 2023, 19, 2780
DOI: 10.1039/D3SM00111C

C Brown, M D G Hughes, D J Brockwell, N Mahmoudi, S Peyman, L Coletta, S Evans, L Dougan, Structural and mechanical properties of folded protein hydrogels with embedded microbubbles, Biomaterials Science, 2023, 11, 2726
DOI: 10.1039/D2BM01918C

H Laurent, TGA Youngs, TF Headen, AK Soper, L Dougan The ability of trimethylamine N-oxide to resist pressure induced perturbations to water structure, Communications Chemistry, 2022, 5, 1

B.S. Hanson, L. Dougan, O.G. Harlen, S.A. Harris, D.J. Read A generalised mechano-kinetic model for use in multiscale simulation protocols

M Nasralla, H Laurent, DL Baker, ME Ries, L Dougan A study of the interaction between TMAO and urea in water using NMR spectroscopy, Physical Chemistry Chemical Physics, 2022

MDH Hughes, BS Hanson, SE Cussons, N Mahmoudi, DJ Brockwell, L Dougan Tuning Protein Hydrogel Mechanics through Modulation of Nanoscale Unfolding and Entanglement in Postgelation Relaxation, ACS Nano, 2022

C. Brown, K. Cook, P.A.Beales and L. Dougan SAWstitch: exploring self-avoiding walks through hand embroidery, Physics Education, 57, 4, 2022

D. Kpeglo, M.D.G. Hughes, L. Dougan, M. Haddrick, M.A. Knowles, S. D.Evans and S.A.Peyman Modeling the Mechanical Stiffness of Pancreatic Ductal Adenocarcinoma, Matrix Biology Plus, 2022, 296

H Laurent, DL Baker, AK Soper, ME Ries, L Dougan Bridging Structure, Dynamics, and Thermodynamics: An Example Study on Aqueous Potassium Halides, The Journal of Physical Chemistry B, 2021, 15, 11296

MDH Hughes, BS Hanson, SE Cussons, N Mahmoudi, DJ Brockwell, L Dougan Control of Nanoscale in situ Protein Unfolding Defines Network Architecture and Mechanics of Protein Hydrogels, ACS Nano, 2021, 15, 11296

BS Hanson, L Dougan Intermediate Structural Hierarchy in Biological Networks Modulates the Fractal Dimension and Force Distribution of Percolating Clusters, Biomacromolecules, 2021 10, 4191 doi/10.1021/acs.biomac.1c00751

H Laurent, DL Baker, AK Soper, ME Ries, L Dougan Solute Specific Perturbations to Water Structure and Dynamics in Tertiary Aqueous Solution, Journal Of Physical Chemistry B, 2020, 124: 10983

A Aufderhorst-Roberts, MDG Hughes, A Hare, DA Head, N Kapur, DJ Brockwell L Dougan, Reaction Rate Governs the Viscoelasticity and Nanostructure of Folded Protein Hydrogels, Biomacromolecules, 2020, 21:4253

BS Hanson, L Dougan Network Growth and Structural Characteristics of Globular Protein Hydrogels, Macromolecules, 2020, 53: 7335

BS Hanson, C Brown, L Dougan Hierarchical Biomechanics: an introductory teaching framework, Physics Education 2020, 55:55022 DOI:

MDH Hughes, SE Cussons, N Mahmoudi, DJ Brockwell, L Dougan Single molecule protein stabilisation translates to macromolecular mechanics of protein network, Soft Matter, 2020, 16: 6389 DOI: 10.1039/C9SM02484K

H Laurent, AK Soper, L Dougan TMAO resists the compression of water structure by magnesium perchlorate: terrestrial kosmotrope vs. Martian chaotrope, PCCP, 2020, 22, 4924-4937

BS Hanson, C Brown, H Laurent, M Hughes, L Dougan Hierarchical Biomechanics: student engagement with a focus on biological physics, Physics Education 55 (2) , 25015, 2020

BS Hanson, D Head, L Dougan The hierarchical emergence of worm-like chain behaviour from globular domain polymer chains Soft Matter 15 (43), 8778-8789, 2019!divAbstract

H Laurent, AK Soper, L Dougan Biomolecular self-assembly under extreme Martian mimetic conditions Molecular Physics 117 (22), 3398-3407, 2019

S Lenton, NH Rhys, JJ Towey, AK Soper, L Dougan Temperature-Dependent Segregation in Alcohol–Water Binary Mixtures Is Driven by Water Clustering The Journal of Physical Chemistry B 122, 7884-7894, 2018

M Batchelor, M Wolny, M Kurzawa, L Dougan, PJ Knight, M Peckham Determining Stable Single Alpha Helical (SAH) Domain Properties by Circular Dichroism and Atomic Force Microscopy Molecular Motors 185-211 2018

Lenton S, Rhys NH, Towey JJ, Soper AK, Dougan L Highly compressed water structure observed in a perchlorate aqueous solution Nature Communications 8, 919-924, 2017

Wolny M, Batchelor M, Bartlett GJ, Baker EG, Kurzawa M, Knight PJ, Dougan L, Woolfson DN, Paci E, Peckham M Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability Scientific Reports 7, 44341, 2017

Alves da Silva M, Lenton S, Hughes M, Brockwell DJ, Dougan L Assessing the potential of folded globular polyproteins as hydrogel building blocks Biomacromolecules 18 636-646, 2017

Tych KM, Batchelor M, Hoffmann T, Wilson MC, Hughes ML, Paci E, Brockwell DJ, Dougan L Differential effects of hydrophobic core packing residues for thermodynamic and mechanical stability of a hyperthermophilic protein. Langmuir : the ACS journal of surfaces and colloids 32 7392-7402, 2016

Lenton S, Walsh DL, Rhys NH, Soper AK, Dougan L Structural evidence for solvent-stabilisation by aspartic acid as a mechanism for halophilic protein stability in high salt concentrations. Physical Chemistry Chemical Physics 18 18054-18062, 2016

Hughes ML, Dougan L The physics of pulling polyproteins: a review of single molecule force spectroscopy using the AFM to study protein unfolding. Reports on Progress in Physics 79 -, 2016

Towey JJ, Soper AK, Dougan L Low-Density Water Structure Observed in a Nanosegregated Cryoprotectant Solution at Low Temperatures from 285 to 238 K Journal of Physical Chemistry B 120 4439-4448, 2016